The National Cancer Clinical Trials Collaborative Learning Network (CCTCLN)

Cancer Clinical Trials Collaborative Learning Network
September 2013-January 2014

Click Here to Read our Final Report on the Learning Network

How the Learning Network Worked to help Cancer Treating Institutions Improve Accrual
Additional Resources


Participation in cancer treatment clinical trials (CCTs) is a key measure for delivery quality cancer care, yet adult trial participation in the U.S. remains under 3%, with even lower participation rates among ethnic and racial minorities and people over 65.  If institutions are to be evaluated by the access they provide to CCTs—such as through the Commission on Cancer’s 2015 guidelines--it is critical to employ effective accrual practices that are grounded in evidence. Unfortunately, there are few evidence-based practices to help sites achieve higher accrual rates. ENACCT is creating this evidence through its leadership of the Cancer Clinical Trial Collaborative Learning Network (CCTCLN).


The CCTCLN was built upon the successful work of the National Pilot Collaborative completed in 2012. The goal of the CCTCLN was to further the goal of the Pilot: to identify practical, patient-centered approaches to increase accrual overall and, in particular, for ethnic /racial minorities and people over 65. 

How the Learning Network Worked to help Cancer Treating Institutions Improve Accrual

Participation in the Network provided research teams with tools and techniques to identify and capitalize on specific opportunities for improvement to expand accrual and increase efficiency with limited clinical research budgets. Over the course of 4 months, the CCTCLN will provided institutions with the skills and tools it needed to begin to improve recruitment and accrual.  Specifically, this process provided:

  • education and training of staff in quality improvement techniques in the context of clinical trials;
  • assessment of  clinical trial “ecosystem” including research culture, trial portfolio, accrual processes, communication effectiveness, staff capacity, operational benchmarks and community outreach;
  • a process map delineating bottlenecks and opportunities for improvement; 
  • an action plan to improve accrual results;
  • a peer network to share experiences and lessons and avoid problems and mistakes;
  • coaching and expertise to expedite and focus efforts; and
  • guidance to help implement practice changes to increase accrual and clinical trial revenue.